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Isaiah Bennett
Isaiah Bennett

Allergology



The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.




allergology



In a search for specialists in allergology you will find medical experts for the diagnosis and treatment of diseases due to allergies. You suffer from an allergy? We will help you find an allergy expert.


The study of allergy and hypersensitivity of the immune system is termed allergology, and thus an allergologist is a medical scientist who studies and practices within that associated field. As suggested above, immunologists also receive allergy training, and specialists in several other disciplines can also be involved in allergy management, including:


Following review of available literature a group of allergy experts within the World Allergy Organization (WAO), representing various continents and areas of allergy expertise, presents this report on risk associated with diagnostic and therapeutic procedures in allergology and proposes a consensus on safety requirements for performing procedures in allergy offices. Optimal safety measures including appropriate location, type and required time of supervision, availability of safety equipment, access to specialized emergency services, etc. for various procedures have been recommended.


The results of venom skin tests must be reviewed and interpreted by an experienced specialist in allergology, in the context of the clinical history of the patient and the natural history of the condition. The pitfalls of diagnostic allergy testing have been well-described [24].


The World Allergy Organization (WAO) is an international umbrella organization whose members consist of 97 regional and national allergology and clinical immunology societies from around the world. By collaborating with member societies, WAO provides direct educational outreach programs, symposia and lectureships to members in nearly 100 countries around the globe.


The World Allergy Organization (WAO) is an international umbrella organization whose members consist of 108 regional and national allergology and clinical immunology societies from around the world. By collaborating with member societies, WAO provides direct educational outreach programs, symposia and lectureships to members in nearly 100 countries around the globe.


The use of telemedical applications, especially video consultation, has experienced a remarkable acceleration in the context of the COVID-19 pandemic. The overview of the legal, technical and professional framework is intended to support the anchoring of digital and telemedical offerings in everyday allergology. However, in order to consolidate these in the future, an agreement is needed regarding professional standards of action as well as a permanently defined remuneration structure beyond the pandemic situation.


A significant number of patients require diagnostic and therapeutic tests that require specialized and controlled care. These tests are carried out at the Allergy Day Hospital, always under the direct supervision of a specialist in allergology and nursing staff, and are detailed below:


The exam is based on revised questions from a question pool prepared by EAACI Task Force members and members from different European centres. These questions are constantly updated and revised. The questions address topics of allergology including allergens, dermatology, respiratory and pediatric allergy, anaphylaxis, venom hypersensitivity, drug and food hypersensitivity. Furthermore, issues such as pregnancy and allergology, occupational allergies, eosinophilic disorders, mastocytosis, and CI-INH deficiency are covered. It also assesses basic immunology and clinical immunology (auto-immunity and immune deficiency). The exam lasts for three hours and has 120 multiple-choice questions, all in English.


Following the initiative of UEMS to standardise the training curriculum of allergologists/clinical immunologists in Europe (Allergy 59:579-588, 2004), the EAACI Knowledge Exam aims to further improve the standards of our specialty by providing a European exam in allergology and clinical immunology.


EAACI Pediatric ExamThis track consists of 120 multiple-choice questions, of which 100 questions are based on allergology and basic / clinical immunology, (70% and 30%, respectively), and 20 are specialised pediatric questions.


The EAACI/UEMS Knowledge Exam is entirely dedicated to allergology and clinical immunology, and aims to further improve the standards of our specialty. In order to make this exam accessible to a wider audience at the safety of your own home, we decided to use a fully digital set up incorporating the latest proctoring levels to guarantee highest security. This presentation will guide you through the different aspects of an online examination, its peculiarities and unique features.


This training program has been created with the aim of providing professionals with specific training in the field of allergology to equip them with the most up-to-date knowledge in diagnosis and intervention.


Molecular allergology is a state-of-the-art approach to allergy diagnostics, whereby defined single allergen components are used for detection of specific IgE in place of traditionally used allergen extracts (Figure 1). The molecular components are highly purified proteins, which are either isolated directly from the allergen source or produced recombinantly. They provide a higher level of standardisation than allergen extracts and enable highly differentiated diagnostics. Molecular allergology systems are a powerful diagnostic tool as they can pinpoint the precise trigger of the allergy, thus facilitating risk assessment and therapy decisions.


Multiplex molecular allergy tests are an indispensable tool for deciding on the optimal strategy for patient management. The tests allow differentiation between cross reactions and multiple sensitisations, which is particularly important for advising patients on the risk of severe allergic reactions. Precise identification of the allergy trigger, moreover, allows selection of patients for SIT who are most likely to benefit from it, thus improving prognosis. Targeted therapy can spare patients the burden of multiple therapies or unnecessary lifestyle changes involved in allergen avoidance. Thus, molecular allergology provides the bedrock for improved patient care and a better quality of life for allergy sufferers.


Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon Publications Allergologia et Immunopathologia is a forum for those working in the field of asthma, allergy and immunology related to childhood. Manuscripts related to clinical, epidemiological and experimental allergology and childhood immunopathology will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology.It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View"section. Letters to the Editor on previously published papers are welcomed.Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc. 041b061a72


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